LIVER FUNCTION ABNORMALITIES AMONG SUBSTANCE ABUSERS: AN IN-DEPTH EXAMINATION

Mohamed Mostafa; Ekramy Nwidu

doi:10.55640/gjmps-abcd111

Open Access

LIVER FUNCTION ABNORMALITIES AMONG SUBSTANCE ABUSERS: AN IN-DEPTH EXAMINATION

https://doi.org/10.55640/gjmps-abcd111

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Mohamed Mostafa ¹ , Ekramy Nwidu ¹ ,

⁴ Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Egypt

⁴ Department of Internal Medicine, Mansoura Nephrology and Dialysis Unit, Egypt

Abstract

Liver function abnormalities are prevalent among individuals with substance abuse disorders, posing significant health risks and complications. This comprehensive analysis examines the spectrum of liver function derangements observed in substance abusers, encompassing alterations in enzyme levels, bilirubin metabolism, and synthetic function. Various substances, including alcohol, illicit drugs, and prescription medications, contribute to hepatotoxicity through different mechanisms, leading to hepatic inflammation, fibrosis, and cirrhosis. The review explores the pathophysiology underlying liver damage induced by substance abuse, emphasizing the interplay between oxidative stress, inflammation, and metabolic dysregulation. Diagnostic modalities for assessing liver function and monitoring disease progression are discussed, highlighting the importance of early detection and intervention to mitigate liver-related complications. Additionally, the impact of substance abuse treatment interventions on liver function outcomes is addressed, emphasizing the need for integrated care models that address both addiction and hepatic health.

Keywords

Liver function, substance abuse, hepatotoxicity

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How to Cite

Mohamed Mostafa, & Ekramy Nwidu. (2023). LIVER FUNCTION ABNORMALITIES AMONG SUBSTANCE ABUSERS: AN IN-DEPTH EXAMINATION. Global Journal of Medical and Pharmaceutical Sciences, 2(10), 01-07. https://doi.org/10.55640/gjmps-abcd111