Transdermal drug delivery systems (TDDS) offer a non-invasive route for drug administration, providing numerous benefits such as improved patient compliance and controlled drug release. This review aims to explore the recent innovations in TDDS, highlighting advancements in technology, formulation strategies, and application areas. We discuss various innovations, including microneedle arrays, iontophoresis, and nanocarrier-based systems, which have enhanced drug permeation and therapeutic efficacy. Despite these advancements, several challenges persist, such as skin irritation, limited drug loading capacity, and variability in drug absorption. The review also addresses these challenges and presents potential solutions. Looking forward, future directions in TDDS are examined, emphasizing the integration of personalized medicine, smart drug delivery systems, and advancements in biocompatible materials. This comprehensive review provides valuable insights for researchers, practitioners, and industry professionals aiming to advance the field of transdermal drug delivery.

Transdermal Drug Delivery, Innovations, Drug Delivery Systems

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