Macular amyloidosis is a dermatological condition characterized by the deposition of amyloid proteins in the skin, particularly in photoexposed areas. This study offers clinical and histological insights into macular amyloidosis, focusing on its presentation, diagnosis, and histopathological features. A comprehensive review of clinical cases and histological specimens was conducted, highlighting common clinical manifestations and characteristic histological findings associated with macular amyloidosis. The study sheds light on the pathogenesis and etiology of the condition, exploring the role of chronic sun exposure and genetic predisposition. Additionally, diagnostic challenges and therapeutic options for macular amyloidosis are discussed, emphasizing the importance of accurate diagnosis and multidisciplinary management approaches.