Cubosomes nanoparticles represent an innovative approach in drug delivery systems, offering unique advantages over traditional delivery methods. This paper explores recent advancements in cubosomes nanoparticles technology and their potential applications in pharmaceutical formulations. We discuss the structural characteristics, fabrication methods, and key properties of cubosomes nanoparticles, highlighting their ability to encapsulate hydrophilic and hydrophobic drugs, enhance drug stability, and facilitate controlled release. Furthermore, we examine the promising applications of cubosomes nanoparticles in targeted drug delivery, vaccine delivery, and theranostics. The review concludes with insights into future directions and challenges in the development and translation of cubosomes nanoparticles-based drug delivery systems.