eISSN: 2791-173X editor@grpublishing.org
All Journals
Submit your article

Global Multidisciplinary Journal

Open Access Peer Review International
Open Access

Synergistic Integration of Pomegranate Peel Extract and Nanocrystalline Delivery Systems: A Comprehensive Analysis of Phytochemical Efficacy, Antimicrobial Action, And Therapeutic Potential in Modern Oncology and Regenerative Medicine

DOI
PDF
Sienna Sterling 1 ,
4 Department of Pharmaceutical Sciences, University of Edinburgh, Germany

Abstract

The utilization of agro-industrial byproducts, specifically the rind and peel of Punica granatum, has emerged as a cornerstone of green pharmacology and sustainable nanomedicine. This research article provides an exhaustive examination of Pomegranate Peel Extract (PPE) and its bioactive constituents, such as punicalagin, gallic acid, and ellagic acid, in the context of advanced drug delivery and therapeutic intervention. By synthesizing data from phytochemical profiling and nano-technological applications, this study investigates how PPE-mediated synthesis of metallic nanoparticles and the encapsulation of extracts within calcium carbonate ,nanocrystals and electrospun nanofibers significantly enhance bioavailability and targeted action. The article further explores the potent antimicrobial properties of PPE in food preservation and wound healing, its role in inhibiting pancreatic and cervical tumor growth through the targeting of tumor-initiating cells and mitochondrial pathways, and its neurobehavioral impact on model organisms like Danio rerio. Through extensive theoretical elaboration, this paper argues that the transition from crude extract application to nano-encapsulated delivery systems represents a paradigm shift in treating chronic inflammation, acute myocardial infarction, and multi-drug resistant microbial infections.

Keywords

Pomegranate Peel Extract, Punicalagin, Nanotechnology, Antimicrobial Activity

References

📄 Agarwal R, Usharani B. Therapeutical Potentials of Pomegranate Peel Extract (PPE) in Zebrafish (Danio rerio): Integrated Phytochemical and Neurobehavioral Assessment. Int J Drug Deliv Technol. 2026;16(19s): 1000-1015. DOI: 10.25258/ijddt.16.19s.115
📄 Baldassarre, F., Vergaro, V., de Castro, F., Biondo, F., Suranna, G. P., Papadia, P., Fanizzi, F. P., Rongai, D., Ciccarella, G., & Osella, D. (2022). Enhanced bioactivity of pomegranate peel extract following controlled release from CaCo3nanocrystals. Bioinorganic Chemistry and Applications, 2022, 1–16. https://doi.org/10.1155/2022/6341298
📄 Bankar, A., Joshi, B., Ravi Kumar, A., & Zinjarde, S. (2010). Banana peel extract mediated synthesis of gold nanoparticles. Colloids and Surfaces B, Biointerfaces, 80(1), 45–50. https://doi.org/10.1016/J.COLSURFB.2010.05.029
📄 Benguigui, M., Weitz, I. S., Timaner, M., Kan, T., Shechter, D., Perlman, O., Sivan, S., Raviv, Z., Azhari, H., & Shaked, Y. (2019). Copper oxide nanoparticles inhibit pancreatic tumor growth primarily by targeting tumor initiating cells. Scientific Reports, 9(1), 1–10. https://doi.org/10.1038/s41598-019-48959-8
📄 Bodbodak, S., Shahabi, N., Mohammadi, M., Ghorbani, M., & Pezeshki, A. (2021). Development of a novel antimicrobial electrospun nanofiber based on polylactic acid/hydroxypropyl methylcellulose containing pomegranate peel extract for active food packaging. Food and Bioprocess Technology, 14(12), 2260–2272. https://doi.org/10.1007/S11947-021-02722-Y
📄 Brannon-Peppas, L., & Blanchette, J. O. (2004). Nanoparticle and targeted systems for cancer therapy. Advanced Drug Delivery Reviews, 56(11), 1649–1659. https://doi.org/10.1016/J.ADDR.2004.02.014
📄 Celiksoy, V., Moses, R. L., Sloan, A. J., Moseley, R., & Heard, C. M. (2020). Evaluation of the in vitro oral wound healing effects of pomegranate (punica granatum) rind extract and punicalagin, in combination with Zn (II). Biomolecules, 10(9), 1234. https://doi.org/10.3390/BIOM10091234
📄 Chen, J., Liao, C., Ouyang, X., Kahramanoǧlu, I., Gan, Y., Li, M., & Rengasamy, K. R. R. (2020). Antimicrobial activity of pomegranate peel and its applications on food preservation. Journal of Food Quality, 2020, 1–8. https://doi.org/10.1155/2020/8850339
📄 Hugo, W.B., & Bloomfield, S.F. (1971). Studies on the mode of action of the phenolic antibacterial agent fentichlor against Staphylococcus aureus and Escherichia coli. 3. The effect of fentichlor on the metabolic activities of Staphylococcus aureus and Escherichia coli. J. Appl. Bacteriol., 34(3), 579-591.
📄 Jiang, Y., Pei, J., Zheng, Y., Miao, Y., Duan, B., & Huang, L. (2022). Gallic acid: a potential anti-cancer agent. Chin. J. Integr. Med., 28. https://doi.org/10.1007/s11655-021-3345-2
📄 Jurenka, J. (2008). Therapeutic Applications of pomegranate (Punica granatum L.): a review. Alternative Medicine Review, 13, 128-144.
📄 Kappen, J., Manurung, J., Fuchs, T., Vemulapalli, S.P.B., Schmitz, L.M., Frolov, A., Agusta, A., Muellner-Riehl, A.N., Griesinger, C., Franke, K., & Wessjohann, L.A. (2023). Challenging structure elucidation of lumnitzeralactone, an ellagic acid derivative from the Mangrove Lumnitzera racemosa. Mar. Drugs., 21. https://doi.org/10.3390/md21040242
📄 Kawai, T. (1996). Fish flavour. Critical Reviews in Food Science and Nutrition, 36, 257-298.
📄 Kim, J., Marshall, M.R., & Wei, C. (2000). Polyphenoloxidase. In Seafood enzymes: Utilization and influence on post harvest seafood quality, Marcel Dekker, New York, 271-315.
📄 Kubo, I., & Kinst-Hori, I. (1998). Tyrosinase inhibitors from cumin. Agricultural Food Chemistry, 46, 5338-5341.
📄 Kumar, A., Mishra, R., Singh, V.D., Mazumder, A., Mazumder, R., & Kumar, A. (2022). Wound healing activity of punicalin and punicalagin isolated from punica granatum L. Rasayan. J. Chem., 15. https://doi.org/10.31788/RJC.2022.1516639
📄 Li, Y., Guo, C., Yang, J., Wei, J., Xu, J., & Cheng, S. (2006). Evaluation of antioxidant properties of pomegranate peel extract in comparison with pomegranate pulp extract. Food Chemistry, 96, 254-260.
📄 Lopez-Caballero, M.E., Martinez-Alvarez, O., Gomez-Guillen, M.D.C., & Montero, P. (2007). Quality of thawed deepwater pink shrimp (Parapenaeus longirostris) treated with melanosis-inhibiting formulations during chilled storage. Food Science and Technology, 42, 1029-1038.
📄 Lu, G., Wang, X., Cheng, M., Wang, S., & Ma, K. (2023). The multifaceted mechanisms of ellagic acid in the treatment of tumors: state-of-the-art. Biomed. Pharmacother., 165. https://doi.org/10.1016/j.biopha.2023.115132
📄 Matinfar, A. (2010). Introduction of Litopenaeus vannamei to shrimp industry of Iran. Final report of research project. I. F.R.O, 42.
📄 Peng, J., Zhao, X., Zhang, M., Li, J., Zhao, C., Wang, S., Wang, J., Shi, H., Zhou, P., & Wang, L. (2023). Punicalagin attenuates ventricular remodeling after acute myocardial infarction via regulating the NLRP3/caspase-1 pathway. Pharm. Biol., 61. https://doi.org/10.1080/13880209.2023.2224403
📄 Zhang, L., Chinnathambi, A., Alharbi, S.A., Veeraraghavan, V.P., Mohan, S.K., & Zhang, G. (2020). Punicalagin promotes the apoptosis in human cervical cancer (ME-180) cells through mitochondrial pathway and by inhibiting the NF-kB signaling pathway. Saudi. J. Biol. Sci., 27. https://doi.org/10.1016/j.sjbs.2020.02.015

How to Cite

Sienna Sterling. (2026). Synergistic Integration of Pomegranate Peel Extract and Nanocrystalline Delivery Systems: A Comprehensive Analysis of Phytochemical Efficacy, Antimicrobial Action, And Therapeutic Potential in Modern Oncology and Regenerative Medicine. Global Multidisciplinary Journal, 5(02), 161-166. https://www.grpublishing.org/journals/index.php/gmj/article/view/417

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 10 > >> 

Similar Articles

1-10 of 14

You may also start an advanced similarity search for this article.