EPIGENETIC INACTIVATION OF TUMOR SUPPRESSOR GENES- MARKER FOR MONITORING THE EFFECTIVENESS OF THERAPY

D.A. Kadirova; N.SH. AVEZOV; A.N. MAKSUDOVA; A.A. IBRAGIMOV

doi:10.55640/gjmps-abcd118

Open Access

EPIGENETIC INACTIVATION OF TUMOR SUPPRESSOR GENES- MARKER FOR MONITORING THE EFFECTIVENESS OF THERAPY

https://doi.org/10.55640/gjmps-abcd118

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D.A. Kadirova ¹ , N.SH. AVEZOV ¹ , A.N. MAKSUDOVA ¹ , A.A. IBRAGIMOV ¹ ,

⁴ Institute of Biophysics and Biochemistry at the National University of the Republic of Uzbekistan. 2

⁴ Institute of Bioorganic Chemistry named after Obid Sodiqov Academy of Sciences of the Republic of Uzbekistan.

⁴ Tashkent Pharmaceutical Institute.

⁴ TASHKENT RESEARCH INSTITUTE OF VACCINES AND SERUM.

Abstract

Epigenetic inactivation of tumor suppressor genes caused by hypermethylation of the promoter area is as characteristic of the tumor process as genetic disorders, serving as an alternative mechanism of the function loss by the tumor suppressor genes. An analysis of the promoter area of RARв2 gene-suppressors has been performed in the normal condition and in breast cancer by methyl-sensitive polymerase chain reaction. Methylation of CpG-dinucleotides in the RARв2 gene promoter area was demonstrated. Abnormal methylation of the RARв2 gene promoter area may be used as a marker for early diagnosis and monitoring of the treatment efficacy in patients with the breast cancer.

Keywords

breast cancer, tumor suppressor, marker, early diagnosis, monitoring of treatment efficacy

References

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How to Cite

Kadirova, D., AVEZOV, N., MAKSUDOVA, A., & IBRAGIMOV, A. (2024). EPIGENETIC INACTIVATION OF TUMOR SUPPRESSOR GENES- MARKER FOR MONITORING THE EFFECTIVENESS OF THERAPY. Global Journal of Medical and Pharmaceutical Sciences, 3(03), 14-19. https://doi.org/10.55640/gjmps-abcd118