Alveolar clefts present a challenging condition in craniofacial surgery, requiring effective and innovative approaches for repair. This study explores the utilization of autogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) as a novel therapeutic strategy for enhancing alveolar cleft repair. Through a comprehensive review of literature and clinical studies, this research investigates the regenerative potential and efficacy of BM-MSCs in promoting bone formation and tissue regeneration within alveolar cleft defects. The mechanisms underlying the osteogenic differentiation and immunomodulatory properties of BM-MSCs are elucidated, highlighting their therapeutic promise in alveolar cleft repair. Furthermore, the safety profile, surgical techniques, and outcomes associated with BM-MSC-based therapies are examined to provide insights into their clinical applicability and future directions in craniofacial reconstruction.

Alveolar cleft repair, Mesenchymal stem cells, Bone marrow-derived

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