AUGMENTING WITHAFERIN-A'S ANTIPROLIFERATIVE POTENTIAL AGAINST EXPERIMENTAL HEPATOCELLULAR CARCINOMA

B. Arun Babu

doi:10.55640/gjmps-abcd08

Open Access

AUGMENTING WITHAFERIN-A'S ANTIPROLIFERATIVE POTENTIAL AGAINST EXPERIMENTAL HEPATOCELLULAR CARCINOMA

https://doi.org/10.55640/gjmps-abcd08

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B. Arun Babu ¹ ,

⁴ Assistant Project Scientist, California University, USA; 3Assistant Professor, 6Guest lecturer, University of Madras, Taramani, Chennai, T N, India

Abstract

Hepatocellular carcinoma (HCC) remains a significant global health concern with limited treatment options. Withaferin-A (WA), a natural compound derived from Withania somnifera, has shown promising antiproliferative effects against various cancer types, including HCC. However, its efficacy as a standalone treatment for HCC is limited. This study investigates strategies to enhance the antiproliferative activity of Withaferin-A against experimental HCC models. Using in vitro and in vivo approaches, we evaluated the synergistic effects of Withaferin-A in combination with other compounds and treatments. Results indicate that combination therapy involving Withaferin-A demonstrates enhanced antiproliferative activity against HCC cells compared to Withaferin-A alone. Furthermore, in vivo studies using experimental HCC models confirm the efficacy of combination therapy in inhibiting tumor growth and improving survival outcomes. These findings highlight the potential of combination therapy involving Withaferin-A as a promising strategy for the treatment of hepatocellular carcinoma.

Keywords

Withaferin-A, Hepatocellular carcinoma, Antiproliferative activity

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How to Cite

AUGMENTING WITHAFERIN-A’S ANTIPROLIFERATIVE POTENTIAL AGAINST EXPERIMENTAL HEPATOCELLULAR CARCINOMA. (2023). Global Journal of Medical and Pharmaceutical Sciences, 2(07), 01-05. https://doi.org/10.55640/gjmps-abcd08