This study investigates the factors contributing to mortality among psychiatric inpatients at a tertiary care hospital. Psychiatric inpatients often face increased mortality rates due to a combination of mental health disorders, comorbid medical conditions, and lifestyle factors. This research aims to identify key contributors to mortality, focusing on clinical, demographic, and social factors. A retrospective analysis was conducted on hospital records of psychiatric inpatients who passed away over a five-year period. Data were collected regarding age, gender, psychiatric diagnosis, comorbidities, duration of hospitalization, and cause of death. The study found that the majority of deaths were associated with comorbid medical conditions such as cardiovascular disease, diabetes, and substance abuse, along with a high incidence of suicide. Age, the presence of chronic psychiatric disorders, and prolonged hospital stays were identified as significant risk factors. The findings suggest the need for integrated healthcare management, which includes both mental health treatment and physical health monitoring, to reduce mortality among psychiatric patients. The study emphasizes the importance of early intervention, multidisciplinary care, and improved patient monitoring in enhancing the survival outcomes of psychiatric inpatients.