Paroxysmal atrial fibrillation (PAF) presents a significant challenge in clinical management due to its recurrent nature and associated risks of stroke and other complications. Radiofrequency ablation (RFA) and cryoablation have emerged as effective strategies for restoring sinus rhythm in patients with PAF. This comprehensive comparative study aims to evaluate the efficacy, safety, and long-term outcomes of RFA versus cryoablation in the treatment of PAF. A thorough analysis of available literature, clinical trials, and observational studies was conducted to assess the procedural success rates, recurrence rates, complication rates, and quality of life outcomes associated with each ablation modality. Factors such as procedural duration, cost-effectiveness, and patient preferences were also considered. The findings of this study provide valuable insights into the optimal selection of ablation techniques for patients with PAF, guiding clinicians in personalized treatment decisions and improving overall patient care.

Paroxysmal atrial fibrillation, Radiofrequency ablation, Cryoablation

Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, et al. HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for patient selection, procedural techniques, patient management and follow -up, definitions, endpoints, and research trial design. Heart Rhythm. 2012; 9: 632-96.

January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, et al. AHA/ACC/HRS guideline for the management of patients with atrial fibrillation.

A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014; 64: 1-76.

Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, et al. ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. The Task Force for the management ofatrial fibrillation of the European Society of Cardiology (ESC). Eur J Cardiothorac Surg. 2016; 37: 2893-962.Wasserlauf J, Pelchovitz DJ, Rhyner J, Verma N, Bohn M, Li Z, et al. Cry balloon versus radiofrequency catheter ablation for paroxysmal atrial fibrillation. Pacing Clin Electrophysiology. 2015; 38: 483-9.

Aryana A, Singh SM, Kowalski M, Pujara DK, Cohen AI, Singh SK, et al. Acute and long-term outcomes of catheter ablation of atrial fibrillation using the second-generation cryoballoon versusOpen-irrigated radiofrequency: A multicenter experience. J Cardiovasc Electrophysiol. 2015; 26: 832-39.

Kuck KH, Fürnkranz A, Chun KR, Metzner A, Ouyang F, Schlüter M, et al. Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation. FIRE AND ICE trial. N Engl J Med. 2016; 374: 2235-45.

Hunter RJ, Baker V, Finlay MC, Duncan ER, Lovell MJ, Tayebjee MH, et al. Point-by-point radiofrequency ablation versusthe cryoballoon or a novel combined approach: A randomized trial comparing 3 methods of pulmonary vein isolation for paroxysmal atrial fibrillation (The Cryo Versus RF Trial). J Cardiovasc Electrophysiol. 2015; 26: 1307-14.

Cardoso R, Mendirichaga R, Fernandes G, Healy C, Lambrakos LK, Viles-Gonzalez JF, et al. Cryoballoon versusradiofrequency catheter ablation in atrial fibrillation: A meta-analysis. J Cardiovasc Electrophysiol. 2016; 27: 1151-9.

Chen CF, Gao XF, Duan X, Chen B, Liu XH, Xu YZ. Comparison of catheter ablation for paroxysmal atrial fibrillation between cryoballoon and radiofrequency: A meta-analysis. J Interv Card Electrophysiol. 2017; 48: 351-66.

Jourda F, Providencia R, Marijon E, Bouzeman A, Hireche H, Khoueiry Z, et al. Contact-force guided radiofrequency vs.second generation balloon cryotherapy for pulmonary vein isolation in patients with paroxysmal atrial fibrillation-A prospective evaluation. Europace. 2015; 17: 225-31. 385