Open Access
Evaluating the Effectiveness of HPV Vaccination in Preventing Oral and Oropharyngeal Cancers Among Men: An Epidemiological Review
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MPHGH, Faculty of Health, Wellbeing & Social Care, Global Banking School, Oxford Brookes University, Manchester, United Kingdom
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MPH, Faculty of Health, Wellbeing & Social Care, Global Banking School, Oxford Brookes University, Manchester, United Kingdom
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PhD, Faculty of Health, Wellbeing & Social Care, Global Banking School, Oxford Brookes University, Birmingham, United Kingdom; and PENKUP Research Institute, Birmingham, United Kingdom
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MDS, Independent Researcher, Manchester, United Kingdom
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PhD, Faculty of Health, Wellbeing & Social Care, Global Banking School, Oxford Brookes University, Manchester, United Kingdom
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PhD, Faculty of Health, Wellbeing & Social Care, Global Banking School, Oxford Brookes University, Birmingham, United Kingdom
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MPH,Faculty of Health, Wellbeing & Social Care, Global Banking School, Oxford Brookes University, Leeds, United Kingdom
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MSc, Department of Project Management, School of Computing, Engineering and Physical Sciences, University of the West of Scotland, United Kingdom
Abstract
Concerns and observations have been expressed regarding the multifaceted nature of Human Papilloma Virus (HPV) infections and their implications for public health, particularly considering recent epidemiological trends and evolving vaccination strategies. HPVs are small double-stranded deoxyribonucleic acid (DNA) viruses approximately 8kb in length from the family Papillomaviridae, long recognized as significant etiological agents for several sexually transmitted diseases, including genital warts. In recent years, however, its role in the pathogenesis of various malignancies, notably cervical and oropharyngeal cancers, has become increasingly evident. The virus primarily infects epithelial cells, residing on the mucosal surfaces—such as the rectum, sexual organs, and oral cavity—as well as on the skin, thereby establishing persistent infections that can culminate in neoplastic transformation.
Keywords
Human Papilloma Virus (HPV),
Vaccination Strategies,
Oropharyngeal Cancer,
Oral Cancer
References
World Health Organization [WHO] Human Papillomavirus (HPV). Available at: https://www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/vaccine-standardization/human-papillomavirus, WHO 2022. [Accessed: 15/11/2021]
Albert E, Laimins L. Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors. Viruses. 2020 Jul 10;12(7):744. Doi:10.3390/v12070744.
Zamani M., Grønhøj C., Jensen D., Carlander A. and Agander T., 2020. The current epidemic of HPV-associated oropharyngeal cancer: An 18-year Danish population-based study with 2,169 patients. European Journal of Cancer, 134, pp.52-59. https://www.ejcancer.com/article/S0959-8049%2820%2930230-6/fulltext.
Volesky K, El-Zein M, Franco E, Brenner D, Friedenreich C. Estimates of the future burden of cancer attributable to infections in Canada. Preventive Medicine, 2019;122:118-127. https://www.sciencedirect.com/science/article/abs/pii/S0091743519301306?via%3Dihub.
Centres for Disease Prevention and Control, HPV Vaccination and Cancer Prevention, CDC. Available at: https://www.cdc.gov/vaccines/vpd/hpv/, [Accessed: 15/11/2021].
D'Souza G, Dempsey A. The role of HPV in head and neck cancer and review of the HPV vaccine. Preventive Medicine. 2011;53:S5-S11. https://www.sciencedirect.com/science/article/pii/S0091743511002908.
Cunningham M, Davison C, Aronson K. HPV vaccine acceptability in Africa: A systematic review. Preventive Medicine. 2014;69:274-279. https://www.sciencedirect.com/science/article/abs/pii/S0091743514003260.
da Cunha A, Bigoni A, Antunes J, Hugo F. The impact of inequalities and health expenditure on mortality due to oral and oropharyngeal cancer in Brazil. Scientific Reports. 2021;11(1). Available at: https://www.nature.com/articles/s41598-021-92207-x#citeas.
National Health Service [NHS], Rubella. 2022. Available at: https://www.nhsinform.scot/illnesses-and-conditions/infections-and-poisoning/rubella, [Accessed: 16/11/2021].
National Health Service [NHS], HPV Vaccine Overview. 2021. Available at: https://www.nhs.uk/conditions/vaccinations/hpv-human-papillomavirus-vaccine/, [Accessed: 16/11/2021].
Stefan V., Xuan W., Karin L., Edith M., Anuj W., et al. Global burden of HPV-related cancers in men: A systematic literature review. Journal of Clinical Oncology May 26, 2019; 37(15): e13108. https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.e13108.
Prem, K., Choi, Y., Bénard, É., Burger, E. and Hadley, L., 2021. Global Impact and Cost-Effectiveness of One-Dose Versus Two-Dose Human Papillomavirus Vaccination Schedules: A Comparative Modelling Analysis. SSRN Electronic Journal, 25(11), p.86. Available at: https://www.medrxiv.org/content/10.1101/2021.02.08.21251186v1.full [Accessed: 7 October 2021].
Cunningham M, Davison C, Aronson K. HPV vaccine acceptability in Africa: A systematic review. Preventive Medicine. 2014;69:274-279. https://www.sciencedirect.com/science/article/pii/S0091743514003260.
Osazuwa-Peters N, Adjei Boakye E, Mohammed K, Tobo B, Geneus C. Not just a woman's business! Understanding men and women's knowledge of HPV, the HPV vaccine, and HPV-associated cancers. Preventive Medicine. 2017;99:299-304. https://www.sciencedirect.com/science/article/pii/S0091743517301123.
Lehtinen M, Apter D, Eriksson T, Harjula K, Hokkanen M. Effectiveness of the AS04‐adjuvanted HPV‐16/18 vaccine in reducing oropharyngeal HPV infections in young females—Results from a community‐randomized trial. International Journal of Cancer. 2019;147(1):170-174. https://onlinelibrary-wiley-com.queens.ezp1.qub.ac.uk/doi/10.1002/ijc.32791.
Mork J, Kathrine A, Glattre E, Clark S, Phil D. Human Papillomavirus Infection as a Risk Factor for Squamous-Cell Carcinoma of the Head and Neck. New England Journal of Medicine. 2001;345(5):376-377. https://www.nejm.org/doi/full/10.1056/NEJM200104123441503.
How to Cite
Motupalli, D., Chauhan, R., Obohwemu, K. O., Sharma, S., Abayomi, G. O., Osinubi, O., Tayo, O. R., & Adejuyitan, S. O. (2025). Evaluating the Effectiveness of HPV Vaccination in Preventing Oral and Oropharyngeal Cancers Among Men: An Epidemiological Review. Global Journal of Medical and Pharmaceutical Sciences, 4(03), 08-13. https://doi.org/10.55640/gjmps/Volume04Issue03-02
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