Pregnancy induces significant physiological changes in the endocrine system, including alterations in thyroid function and iodine metabolism. Central sensitivity to thyroid hormones (TH) and urinary iodine levels are two essential factors that influence maternal and fetal health. This study explores the relationship between central sensitivity to thyroid hormones and changes in urinary iodine during pregnancy. We examine how these factors are interconnected, considering the unique metabolic demands during pregnancy and the potential effects on maternal and fetal thyroid health. We find that while both thyroid hormone sensitivity and urinary iodine levels fluctuate throughout pregnancy, their interplay can significantly affect pregnancy outcomes, particularly in iodine-deficient populations.